Abstract: Aiming at the problem of additional power loss caused by different LED conduction voltage drop, a multi-channel LED backlight drive control circuit with adaptive control is designed. Through adaptive control, the voltage on the linear current regulator is minimized. Based on 0.18 μm BCD process, a linear current regulator suitable for adaptive control is built, which can realize linear adjustment of channel current from 0 to 48 mA, and the current resolution is 0.2 mA. At different process angles and temperatures, the error of full current range is less than 0.1 %, and the layout area is 0.504 mm². The simulation results show that when the channel current is 20 mA, the power efficiency of the three-channel LED drive circuit with adaptive control is 95.2 %, and the power loss of the linear current regulator is reduced by 74 %.