Abstract: To meet the multi-standard compatibility requirements in heterogeneous protocol interconnection systems, this paper proposes a SerDes circuit architecture designed for multi-protocol interconnection. The architecture consists of eight lanes and a clock module, in which a coordinated clock circuit based on QPLL and LanePLL enables multi-frequency, low-jitter clock generation and supports multi-protocol lane bonding. At the transmitter, a dual-path half-rate PAM4 signal generation scheme based on DACs is employed, together with compensation and equalization circuits to ensure data transmission reliability. The receiver incorporates a feed-forward equalizer and an adaptive equalization circuit based on the SS-LMS algorithm, forming a fully adaptive equalization system. Test results show that the proposed SerDes circuit supports both NRZ and PAM4 transmission modes. At 53.125 Gbps, the transmitter exhibits a random jitter of 15.1 mUI, a maximum power consumption of 11.18 mW/Gbps, and a maximum insertion loss compensation of 38 dB. Furthermore, the transmitter eye diagram, receiver jitter tolerance, and bit error rate all meet the standard specifications of mainstream protocols including PCIe, Ethernet, RapidIO, and FC.